Terrein (>95% Purity)
InVitvo Pharmaceuticals
For Research Use Only (RUO). Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.
High Purity Terrein for Research
Bioactive Fungal Metabolite (CAS: 16014-58-7)
Terrein is a highly bioactive secondary metabolite natively isolated from endemic Canadian soil strains of Aspergillus terreus. At InVitvo Pharmaceuticals, we utilize proprietary semi-industrial fungal fermentation to produce Terrein at analytical grades exceeding 95% purity.
As a potent inhibitor of biological pathways, Terrein has become a molecule of significant interest in preclinical oncology, dermatology (melanogenesis inhibition), and antimicrobial resistance research.
Terrein Molecular Structure (C₈H₁₀O₃)
Available Quantities & Pricing
We supply standard analytical amounts and offer scalable bulk custom synthesis for extensive lead optimization campaigns.
| SKU / Catalog | Quantity | Price |
|---|---|---|
| INV-TER-005 | 5 mg | C$450 |
| INV-TER-010 | 10 mg | C$800 |
| INV-TER-XXX | Custom / Bulk | Inquire for Quote |
Technical Specifications
| Chemical Name | Terrein |
| IUPAC Name | (4S,5R)-4,5-dihydroxy-3-[(1E)-prop-1-en-1-yl]cyclopent-2-en-1-one |
| Molecular Formula | C₈H₁₀O₃ |
| Molecular Weight | 154.16 g/mol |
| CAS Number | 16014-58-7 |
| Purity | >95% (UHPLC) |
| Source | Aspergillus terreus (Canadian Endemic Strain) |
| Physical Form | Crystalline powder or lyophilized solid |
| Solubility | DMSO, Methanol, Ethanol |
Quality Control Methods
UHPLC
Chromatographic purity >95% determination using established calibration curves.
NMR Spectroscopy
Direct ¹H and ¹³C NMR to confirm absolute structural integrity and stereochemistry.
Mass Spectrometry
Tandem MS for molecular weight verification and fragmentation profiling.
Documentation Included
Every order ships with a batch-specific COA and SDS to ensure compliance and traceability across your assays.
Preclinical Applications & Literature
Terrein demonstrates pleiotropic biological activities that make it an exceptional compound for diverse laboratory investigations.
Preclinical Oncology
In vitro studies highlight Terrein's ability to inhibit STAT3 pathways and induce apoptotic responses in specific human cancer cell lines.
Dermatology Models
Demonstrated as a powerful melanogenesis inhibitor by causing MITF protein degradation, making it valuable for pigmentation research.
Antimicrobial Research
Serves as a reference compound for baseline antifungal and antibacterial assays when isolating novel soil metabolites.
Selected Peer-Reviewed References
Zaehle C, et al. (2014) Terrein biosynthesis in Aspergillus terreus and its impact on phytotoxicity. Chemistry & Biology, 21(6), 719-731.
Key insights into the multi-gene cluster responsible for terrein biosynthesis.
Lee JC, et al. (2010) Terrein inhibits STAT3 activity and induces apoptosis in human cancer cells. Anticancer Research, 30(10), 3951-3955.
Provides an in vitro baseline for terrein's anticancer potential.
Arakawa M, et al. (2002) Antibacterial and antifungal activity of terrein. Biological & Pharmaceutical Bulletin, 25(5), 645-649.
Fundamental antimicrobial activity assays spanning gram-positive and fungal strains.
Storage & Handling
- • Storage Conditions: Ship at ambient temperature. Store at -20°C for long-term stability up to 24 months.
- • Protection: Store in tightly sealed vials away from direct light and moisture.
- • Handling: Handle exclusively within a certified fume hood or ventilated environment using standard PPE (nitrile gloves, lab coat, safety glasses).
- • Preparation: Soluble in DMSO (recommended to make stock solutions immediately before use).
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